Human(6872) Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.[provided by RefSeq, Aug 2009]
Mouse(270627) TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor
Rat(317256) TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor
Domestic Rabbit(100348935) TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
naked mole-rat(101705178) TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
cow(504792) TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
cow(785085) TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
sheep(101123273) TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_004606
Rosetta Predictions
human
pricing
NM_138923
Rosetta Predictions
human
pricing
XM_001061884
Rosetta Predictions
rat
pricing
XM_228551
Rosetta Predictions
rat
pricing
NM_001081008
Rosetta Predictions
mouse
pricing
XM_001000569
Rosetta Predictions
mouse
pricing
XM_194622
Rosetta Predictions
mouse
pricing
XM_886564
Rosetta Predictions
mouse
pricing
XM_896863
Rosetta Predictions
mouse
pricing
XM_896872
Rosetta Predictions
mouse
pricing
XM_896882
Rosetta Predictions
mouse
pricing
XM_896906
Rosetta Predictions
mouse
pricing
XM_896918
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_004606
VALIDATED
TAF1 MISSION shRNA Bacterial Glycerol Stock TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
Human
14 Products Total
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