Human(6923) Summary: This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]
Mouse(67673) transcription elongation factor B (SIII), polypeptide 2
Rat(81807) transcription elongation factor B (SIII), polypeptide 2
Zebrafish(192341) transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B)
domestic cat(100628310) transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
dog(479873) transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
cow(617277) transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
Goat(100861051) transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
Save up to 60% per TRCN when you buy a set with the same options.
MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
Custom Gene Products
Our expertise in DNA & RNA oligo design, chemistry and manufacturing enable Sigma Custom Products to provide a comprehensive product portfolio. Learn more about our "custom capabilities & extensive options today."
siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_007108
Rosetta Predictions
human
pricing
NM_207013
Rosetta Predictions
human
pricing
NM_031129
Rosetta Predictions
rat
pricing
NM_026305
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_007108
VALIDATED
TCEB2 MISSION shRNA Bacterial Glycerol Stock transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
Human
13 Products Total
TRC Number
Price
Set Price (5+)?
Select
We do not support the configuration options you have chosen
