Human(6923) Summary: This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]
Mouse(67673) transcription elongation factor B (SIII), polypeptide 2
Rat(81807) transcription elongation factor B (SIII), polypeptide 2
Zebrafish(192341) transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B)
domestic cat(100628310) transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
dog(479873) transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
cow(617277) transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
Goat(100861051) transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
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Product #
siRNA Type
Species
NM_007108
Rosetta Predictions
human
pricing
NM_207013
Rosetta Predictions
human
pricing
NM_031129
Rosetta Predictions
rat
pricing
NM_026305
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_007108
VALIDATED
TCEB2 MISSION shRNA Bacterial Glycerol Stock transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
Human
13 Products Total
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