TCF3

Human(6929) Summary: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

Mouse(21423) transcription factor 3

Rat(171046) transcription factor 3

domestic guinea pig(100733634) transcription factor 3

naked mole-rat(101725133) transcription factor 3

cow(530616) transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

sheep(100913162) transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

chicken(395146) transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

Horse(100147220) transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

domestic cat(101098930) transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

dog(485079) transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)