Human(79600) Summary: This gene encodes a member of the tectonic family of secreted and transmembrane proteins. The orthologous gene in mouse is required for formation of most ventral cell types. It functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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MISSION® siRNAs have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. The Rosetta-powered siRNA design algorithm has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications. New and critical siRNA design rules incorporated into the latest algorithm lead to increased target specificity and knockdown for low abundance messages.
Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_001082537
Rosetta Predictions
human
pricing
NM_001082538
Rosetta Predictions
human
pricing
NM_024549
Rosetta Predictions
human
pricing
XM_222188
Rosetta Predictions
rat
pricing
XR_009299
Rosetta Predictions
rat
pricing
NM_001039153
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_024549
VALIDATED
TCTN1 MISSION shRNA Bacterial Glycerol Stock tectonic family member 1
Human
18 Products Total
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