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TOP1MT

topoisomerase (DNA) I, mitochondrial

45 Gene Product Result for
UniProtKB ID: Q969P6, B7ZAR5, E7ES89, Q86ST4, Q86V82
Gene ID:
Human(116447) Summary: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Mouse(72960) DNA topoisomerase 1, mitochondrial
Rat(300029) topoisomerase (DNA) I, mitochondrial
Zebrafish(415098) mitochondrial topoisomerase I
chicken(408025) topoisomerase (DNA) I, mitochondrial
cow(618382) topoisomerase (DNA) I, mitochondrial
sheep(101114532) topoisomerase (DNA) I, mitochondrial
naked mole-rat(101726319) topoisomerase (DNA) I, mitochondrial
domestic guinea pig(100728586) topoisomerase (DNA) I, mitochondrial
Custom Gene Products
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shRNA

Type Description Species Add to Cart
 

esiRNA

Product # Description Species Add to Cart
 
EHU009411 MISSION® esiRNA esiRNA targeting human TOP1MT (esiRNA1) human pricing

Custom CRISPR Plasmid

Product # Description  
 
CRISPR Custom CRISPR Plasmid for gene knockout

siRNA

siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm.
All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product # siRNA Type Species  
 
NM_052963 Rosetta Predictions human pricing
NM_001002798 Rosetta Predictions rat pricing
NM_028404 Rosetta Predictions mouse pricing
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_052963 Rosetta Predictions Human
Ranking siRNA ID Sequence Start ?
1 SASI_Hs01_00151452 predicted 782
2 SASI_Hs01_00151453 predicted 1081
3 SASI_Hs01_00151454 predicted 308
4 SASI_Hs01_00151455 predicted 1356
5 SASI_Hs02_00361767 predicted 423
6 SASI_Hs01_00151456 predicted 837
7 SASI_Hs01_00151457 predicted 1161
8 SASI_Hs01_00151458 predicted 1466
9 SASI_Hs01_00151459 predicted 1281
10 SASI_Hs01_00151460 predicted 530
11 SASI_Hs01_00151461 predicted 910
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_001002798 Rosetta Predictions Rat
Ranking siRNA ID Sequence Start ?
1 SASI_Rn01_00098118 predicted 283
2 SASI_Rn01_00098119 predicted 881
3 SASI_Rn01_00098120 predicted 828
4 SASI_Rn01_00098121 predicted 523
5 SASI_Rn01_00098123 predicted 1212
6 SASI_Rn01_00098124 predicted 779
7 SASI_Rn02_00197980 predicted 673
8 SASI_Rn01_00098126 predicted 780
9 SASI_Rn01_00098127 predicted 1217
10 SASI_Rn02_00197981 predicted 1103
11 SASI_Rn01_00098122 predicted 1402
12 SASI_Rn01_00098125 predicted 1113
siRNA
PRODUCT # siRNA Type ? SPECIES
NM_028404 Rosetta Predictions Mouse
Ranking siRNA ID Sequence Start ?
1 SASI_Mm01_00150285 predicted 526
2 SASI_Mm01_00150286 predicted 528
3 SASI_Mm01_00150287 predicted 413
4 SASI_Mm01_00150288 predicted 396
5 SASI_Mm01_00150289 predicted 827
6 SASI_Mm01_00150290 predicted 328
7 SASI_Mm01_00150291 predicted 1610
8 SASI_Mm01_00150292 predicted 1405
9 SASI_Mm01_00150293 predicted 877
10 SASI_Mm01_00150294 predicted 779