Human(51366) Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Mouse(70790) ubiquitin protein ligase E3 component n-recognin 5
Rat(117060) ubiquitin protein ligase E3 component n-recognin 5
Zebrafish(334627) ubiquitin protein ligase E3 component n-recognin 5
chicken(420252) ubiquitin protein ligase E3 component n-recognin 5
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
