Human(51776) Summary: This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Mouse(65964) sterile alpha motif and leucine zipper containing kinase AZK
Rat(311743) sterile alpha motif and leucine zipper containing kinase AZK
chicken(424149) sterile alpha motif and leucine zipper containing kinase AZK
dog(478802) sterile alpha motif and leucine zipper containing kinase AZK
cow(519251) sterile alpha motif and leucine zipper containing kinase AZK
Gene Class:
Cytoskeleton
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Validated MISSION® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. With Validated MISSION® siRNAs, we have done the upfront validation work, so that you do not have to.
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siRNA ranking are listed in order of expected efficacy (1 being the best) as predicted by the Rosetta algorithm. All predesigned siRNA carry the Sigma-Aldrich guarantee.
Product #
siRNA Type
Species
NM_016653
Rosetta Predictions
human
pricing
NM_133646
Rosetta Predictions
human
pricing
XM_001059755
Rosetta Predictions
rat
pricing
XM_230983
Rosetta Predictions
rat
pricing
NM_023057
Rosetta Predictions
mouse
pricing
NM_178084
Rosetta Predictions
mouse
pricing
shRNA
PRODUCT TYPE
PRODUCT NAME
SPECIES
SHCLNG-NM_016653
VALIDATED
ZAK MISSION shRNA Bacterial Glycerol Stock
Human
15 Products Total
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