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Bioorganic & medicinal chemistry letters

Polymer-bound N-hydroxysuccinimide esters: a column-free fluorescent-labeling method.


PMID 10206554

Abstract

Polymer-bound N-hydroxysuccinimide esters of 1-pyrenebutyric acid, 6-carboxyfluorescein diacetate, and biotin were efficiently prepared. Column-free fluorescent- and biotin-labeling reactions of various amines using these resins were successfully demonstrated.