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Journal of chemotherapy (Florence, Italy)

Comparative study of the in vitro antifungal activity of bifonazole, naftifine and sertaconazole against yeasts.


PMID 10435679

Abstract

The in vitro activity of three antifungal agents was tested and compared against 151 yeast strains, including ten Candida species, Cryptococcus neoformans, Rhodotorula rubra, and Trichosporon cutaneum. Minimum inhibitory concentrations (MICs) were determined by a microdilution technique in Shadomy modified liquid medium. The mean MICs of sertaconazole (0.34 mg/L) were lower than those of naftifine (16.3 mg/L) and bifonazole (13.2 mg/L). These results suggest that sertaconazole is more active against Candida spp than other topical agents such as bifonazole and naftifine.

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N1790
Naftifine hydrochloride
C21H21N · HCl