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Bioorganic & medicinal chemistry letters

Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation.


PMID 10450959

Abstract

Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described.