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Bioorganic & medicinal chemistry letters

Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol.


PMID 10465529

Abstract

Novel analogs of (-)-delta8-tetrahydrocannabinol (delta8-THC) in which the conformation of the side chain was restricted by incorporating the first one or two carbons into a six membered ring fused with the aromatic phenolic A ring were synthesized. The affinities of the novel ligands for CB1 and CB2 indicated that the "southbound" chain conformer retained the highest affinity for both receptors.

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