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Bioorganic & medicinal chemistry letters

Convenient synthesis of L-proline benzyl ester.


PMID 10560736

Abstract

Mesylates or tosylates of delta-hydroxy-L-norvaline esters spontaneously afford L-proline esters upon exposure to aqueous buffer in near quantitative yield. This novel reaction has led to the development of a simple route to optically active proline esters.

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364460
L-Proline benzyl ester hydrochloride, 98%
C12H15NO2 · HCl