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Bioorganic & medicinal chemistry letters

Design, synthesis and DNA-cleavage of Gly-Gly-His-naphthalene diimide conjugates.


PMID 10571151

Abstract

Naphthalene diimides with one and two metal-chelating Gly-Gly-His (GGH) motifs have been synthesized. Both conjugates induce single-stranded cleavage of plasmid pBR322 DNA in the presence of nickel and Oxone and are approximately 100-fold more efficient than Ni(II) x GH-CONH2 itself.

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G4541 Gly-Gly-His
C10H15N5O4