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Bioscience, biotechnology, and biochemistry

Asymmetric reduction of ethyl 2-methyl e-oxobutanoate by fungi.


PMID 10766507

Abstract

Seven fungi, which are found to reduce ethyl 3-oxobutanoate in high yields, were tested for their reducing ability for ethyl 2-methyl 3-oxobutanoate. We obtained some interesting findings. In particular, Penicillium purpurogenum reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 93/7 with the enantiomeric excess of anti-(2S,3S)- and syn-(2S,3R)- hydroxy esters of 90 and >99 ee%, respectively.

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E35400
Ethyl 2-methylacetoacetate, 90%
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