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Journal of pharmaceutical and biomedical analysis

Investigation and analytical application of the reactions of eriochrome cyanine R with fluvoxamine and fluoxetine.


PMID 10933541

Abstract

Eriochrome cyanine R (ECR) reacts with fluvoxamine (FXM) and fluoxetine (FXT) forming coloured ion-association compounds. The composition of the compounds, studied by spectrophometric methods showed that the molar ratio ECR:FXM = 1:2 and ECR:FXT = 1:2. The formation and extraction conditions of the compounds were established. The compounds were characterised by UV, VIS, and IR spectrometry. It was found that the compounds are insoluble in water but quantitatively extracted into buthanol. Under the optimal experimental conditions fluvoxamine and fluoxetine were determined in the range 2-40 microg/ml and 2-20 microg/ml, respectively. The relative standard deviation is about +/- 2%.