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Bioorganic & medicinal chemistry letters

Solid-phase synthesis of acridine-based threading intercalator peptides.


PMID 10987431

Abstract

The preparation of a novel acridine-based amino acid is reported. This N-Alloc-protected monomer can be coupled and deprotected under solid-phase peptide synthesis procedures to create acridine peptide conjugates as potential threading intercalators. A peptide containing this novel amino acid undergoes spectral changes in the presence of duplex DNA and RNA consistent with intercalative binding.

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