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Acta poloniae pharmaceutica

A study of the relationship between the structure of homologous series of oxprenolol at various pH values.


PMID 11126025

Abstract

Stability of series of O-acyl esters of oxprenolol prepared as potential pro-drugs, is investigated over the pH range 0.4-10 at 37 degrees C. Maximum stability of all esters occurred at pH 3-4. The most stable derivative was found to be pivaloyl ester. The relationship between Charton Steric parameters (v) and the catalytic rate constant of hydrolysis is investigated.

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O0250000 Oxprenolol hydrochloride, European Pharmacopoeia (EP) Reference Standard
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