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Bioorganic & medicinal chemistry

Lipase catalysed synthesis of optically enriched alpha-haloamides.


PMID 11377191

Abstract

An efficient lipase catalysed synthesis of optically enriched alpha-halogenated amides with concomitant optical enrichment of the starting alpha-haloesters is described. Candida antarctica lipase (CAL) was found to be a better catalyst over porcine pancreatic lipase (PPL) and Candida cylindracea lipase (CCL). The effect of different organic solvents was also studied.