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Bioorganic & medicinal chemistry letters

Nicotinamide N-oxides as CXCR2 antagonists.


PMID 11459668

Abstract

A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, auto-immune, and allergic disorders.