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The Analyst

Preliminary studies of a fast screening method for cocaine and cocaine metabolites in urine using hollow fibre membrane solvent microextraction (HFMSME).


PMID 11534596

Abstract

A simple and efficient screening method for cocaine and cocaine metabolites has been developed using an inexpensive, disposable hollow fibre membrane. Drug extraction was achieved using hollow fibre membrane solvent microextraction (HFMSME). Extraction and separation, using a gas chromatograph, was achieved in less than 7.5 min. Using HFMSME, concentrations below 0.050 microg mL(-1) were measurable. Good reproducibility was achieved when an internal standard was used, producing relative standard deviation values averaging 5.4%. The effects of various adulterants and interferents on the screening technique were studied and a direct comparison to drop solvent microextraction was made.