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Journal of ethnopharmacology

Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites.


PMID 11585687

Abstract

The ethanolic extract of Clerodendrum petasites was tested to evaluate the spasmolytic activity on isolated guinea-pig tracheal smooth muscle. The crude extract (2.25-9.0 mg/ml) dose-dependently caused relaxation of tracheal smooth muscle which was contracted by exposure to histamine. A bioassay-guided fractionation of the crude extract was performed by means of partitioning and centrifugal partition chromatography. Finally the active principle was isolated and identified as the flavonoid hispidulin (EC(50): (3.0+/-0.8)x10(-5) M). These results suggest that hispidulin may be beneficial in the treatment of asthma.

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SML0582 Hispidulin, ≥98% (HPLC)
C16H12 O6