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Advances in experimental medicine and biology

Synthesis of taurine analogues from alkenes: preparation of 2-aminocycloalkanesulfonic acids.


PMID 11787625

Abstract

(+/-)trans 2-Aminocyclohexanesulfonic acid and (+/-)trans 2-aminocyclopentanesulfonic acid were prepared from cyclohexene and cyclopentene respectively by sulfur monochloride addition, followed by oxidation to 2-chlorosulfonic acid and substitution of chlorine.