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Archives of toxicology

Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin.


PMID 11914777

Abstract

Covalent binding of various clinically important nitrogen mustards to the cysteine-34 residue of human serum albumin, in vitro and in vivo, is demonstrated. A rapid method for detection of these adducts is presented, based on liquid chromatography-tandem mass spectrometry analysis of the adducted tripeptide Cys*-Pro-Phe after digestion of the protein with Pronase.

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