EMAIL THIS PAGE TO A FRIEND

Sheng li xue bao : [Acta physiologica Sinica]

[Cardiovascular effects of lateral intracerebroventricular injection of L-securinine].


PMID 11941410

Abstract

To investigate cardiovascular effects of changed GABAergic tonic activation in periventricular forebrain, arterial pressure (AP), heart rate (HR) and renal sympathetic nerve discharge (RSND) were recorded in anesthetized rats when L-securinine (L-Sec) was administered into the lateral intracerebroventricle. L-Sec elicited dose-dependent increases in RSND, AP and HR, which were much weaker than those of bicuculline. L-Sec antagonized the sympatho-inhibitory and depressor effects evoked by both muscimol and baclofen. These results indicate that GABAergic inhibition originating from periventricular forebrain may suppress tonically sympathetic outflow to cardiovascular system which is disinhibited by L-Sec, and L-Sec is likely an unselective GABA receptor antagonist.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SML0055
Securinine, ≥98% (HPLC)
C13H15NO2