EMAIL THIS PAGE TO A FRIEND

Journal of pharmaceutical and biomedical analysis

SPME-LC with UV detection to study delorazepam-serum albumin interactions.


PMID 12093523

Abstract

Solid phase microextraction coupled to high performance liquid chromatography with UV detection (SPME/LC-UV) has been employed to study the binding of delorazepam to human serum albumin (HSA) and bovine serum albumin (BSA). The procedure could also be potentially extended to the measurement of partition coefficients between a wide variety of semi- or non-volatile compounds and matrices. The method is solvent free, simple, fast, and drawbacks of the conventional analytical techniques are avoided. Moreover, the matrix did not interfere with the measurement by binding to the fibre and the amount extracted by the fibre was negligibly small; thus it did not disturb the delorazepam-protein binding.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

D7662
Delorazepam
C15H10Cl2N2O