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Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Lipase-catalyzed enantioselective ammonolysis of racemic phenylglycine methyl ester in organic solvent].


PMID 12148293

Abstract

A novel reaction-enzymatic ammonolysis discovered in the mid of 1990s has been demonstrated to be a very promising alternative in the preparation of optically pure compounds. The effects of organic solvent, initial water activity, temperature and additives on lipase Novozym435-catalyzed enantioselective ammonolysis of racemic phenylglycine methyl ester were investigated systematically in this paper. Enzymatic reaction of ammonolysis showed higher activity and enantioselectivity than the corresponding reaction of hydrolysis and alcoholysis.

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307882
(R)-(−)-2-Phenylglycine methyl ester hydrochloride, ≥95%
C9H11NO2 · HCl