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Bioorganic & medicinal chemistry letters

Chemical modification of reveromycin A and its biological activities.


PMID 12419362

Abstract

Various derivatives of reveromycin A, a novel inhibitor of eukaryotic cell growth, were prepared and their inhibitory effects on both isoleucyl-tRNA synthetase activity and in vitro protein synthesis, and activities on the morphological reversion of src(ts)-NRK cells were assayed. The C5 hydroxyl group and C24 carboxyl group are particularly important for these activities.

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R0654
Reveromycin A, solid
C36H52O11