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Drug development and industrial pharmacy

Solubilization of (+)-limonene by anionic/cationic mixed surfactant systems.


PMID 12741615

Abstract

The combined effects of sodium n-octyl sulfate (SOS) and cetyltrimethylammonium bromide (CTAB) on the solubilization of (+)-limonene in aqueous solution were studied using a headspace gas chromatography technique. The findings showed the mixing of SOS and CTAB resulted in positive synergistic effects on the solubility of (+)-limonene. The positive synergistic effects are explained from the perspective of the phase behavior of this mixed surfactant system.