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Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Photophysical properties of 5-methylcytidine.


PMID 12760530

Abstract

Cytosine methylation, which determines the hot spots for DNA photo-damage, is shown to induce a red-shift of the nucleoside absorption spectrum, making the chromophore more vulnerable to solar radiation, and a tenfold increase of the fluorescence lifetime, making excited statereactions more probable. A femtosecond investigation of the excited state deactivation reveals a quite complex mechanism.