EMAIL THIS PAGE TO A FRIEND

Rapid communications in mass spectrometry : RCM

Feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry in analysis of drugs.


PMID 12811757

Abstract

The feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP-DIOS-MS) for drug analysis was investigated. It was observed that only compounds with relative high proton affinity are efficiently ionized under AP-DIOS conditions. The limits of detection (LODs) achieved in MS mode with midazolam, propranolol, and angiotensin II were 80 fmol, 20 pmol, and 1 pmol, respectively. In MS/MS mode the LODs for midazolam and propranolol were 10 fmol and 5 pmol, respectively. The good linearity (r(2) > 0.991), linear dynamic range of 3 orders of magnitude, and reasonable repeatability showed that the method is suitable for quantitative analysis.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

N4002
2-Naphthaleneacetic acid, 99%
C12H10O2