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Nucleic acids symposium series

Photochemical deoxyribose C2' oxidation in 5-iodouracil-containing hexanucleotide.


PMID 1289829

Abstract

To investigate photochemistry of 5-iodouracil (IU) in DNA, photoreaction of IU-containing oligonucleotides was examined. It was found that d(GCAIU G C) 2 undergoes selective photochemical C1' and C2' oxidation at the 5' side of IU residue to provide ribonolactone-containing hexamer 1 and erythrose-containing hexamer 2. Upon heating under alkaline conditions, erythrose-containing hexamer 2 was found to undergo retro aldol condensation to provide two fragments having glycolaldehyde termini.

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857858
5-Iodouracil, 98%
C4H3IN2O2