EMAIL THIS PAGE TO A FRIEND

Organic letters

Approach to the synthesis of dolabelides A and B: fragment synthesis by tandem silylformylation-crotylsilylation.


PMID 12967318

Abstract

[structure: see text] A synthesis of the C(15)-C(30) fragment of Dolabelides A and B has been achieved. The recently developed asymmetric silane alcoholysis and tandem silylformylation-crotylsilylation reactions were used as the key steps to establish the C(23)-C(27) 1,5-syn-diol. In addition, the flexibility of this methodology has been demonstrated with an efficient synthesis of the C(24)-C(25) trisubstituted olefin.