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Biochemistry international

Effects of ethanol and its fluorinated analogues on the calcium ATPase of sarcoplasmic reticulum.


PMID 1385948

Abstract

The effects of ethanol, monofluoro- and trifluoroethanol on the hydrolysis of ATP and coupled Ca2+ translocation by sarcoplasmic reticulum Ca(2+)-ATPase (EC 3.6.1.38) were measured. All three alcohols had parallel effects on the enzyme activities at concentrations up to 200 mM, suggesting a similar mechanism of action. 19F nuclear magnetic resonance spectroscopy was used to investigate their site of action in the purified enzyme.

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2-Fluoroethanol, 95%
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