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Bioorganicheskaia khimiia

[Synthesis of oligodeoxyribonucleotides containing 5-fluoro-2'-deoxyribocytidine].


PMID 1417995

Abstract

A synthesis of the phosphoroamidite derivative of 5-fluoro-2'-deoxycytidine which allows one to introduce the modified nucleoside residue into the 5'-position of the oligodeoxyribonucleotide by the standard solid phase phosphoroamidite method, has been carried out. Oligonucleotides with 5-fluoro-2'-deoxycytidine residues in various positions of the DNA strand are obtained by the combination of chemical and enzymatic syntheses.

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F5307
5−Fluoro−2′−deoxycytidine, ≥98% (HPLC), powder
C9H12FN3O4