EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry letters

Synthesis and AMPA receptor antagonistic activity of a novel class of quinoxalinecarboxylic acid with a substituted phenyl group at the C-7 position.


PMID 14505662

Abstract

The synthesis and biological properties of a novel class of 7-heterocycle-substituted quinoxalinecarboxylic acids, which bear a substituted phenyl group through a urethane linkage at the C-7 position, are described. One of the synthesized compounds, 15l, which has a 4-carboxyphenyl carbamoyloxymethyl imidazole group at the C-7 position and is water-soluble, was found to possess high potency in vitro and showed excellent neuroprotective efficacy in vivo.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

293407
2-Quinoxalinecarboxylic acid, 97%
C9H6N2O2