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Nucleosides, nucleotides & nucleic acids

Introduction of a benzyl group onto the 2'-OH of 6-chloropurine 3'-O-benzoylriboside.


PMID 14565277

Abstract

A new method to introduce a benzyl group onto the 2'-OH of purine ribonucleoside is described. Thus, 6-chloropurine 3'-O-benzoylriboside and its 5'-O-trityl congener were condensed with benzyl alcohol using the Mitsunobu reaction to give the 2'-O-benzyl derivative. The yields were varied from 4.6 to 62.9% depending on the solvent. The product was converted to adenosine, indicating that the stereochemistry at C-2' is retained.

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C8276
6-Chloropurine riboside
C10H11ClN4O4
852481
6-Chloropurine riboside, 99%
C10H11ClN4O4