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Archives of pharmacal research

Cholinesterase inhibitory activity of two farnesylacetone derivatives from the brown alga Sargassum sagamianum.


PMID 14609125

Abstract

Two known farnesylacetone derivatives (1 and 2) were isolated from the Korean brown alga Sargassum sagamianum off Jeju Island, Korea. Compounds 1 and 2 were identified as (5E,10Z)-6,10,14-trimethylpentadeca-5,10-dien-2,12-dione and (5E,9E,13E)-6,10,4-trimethyl-pentadeca-5,9,13-trien-2,12-dione, respectively, by comparison with the literature data. Compounds 1 and 2 showed moderate acetylcholinesterase and butyrylcholinesterase inhibitory activities with IC50 values of 65.0 approximately 48.0 and 34.0 approximately 23.0 microM, respectively.

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46195
Farnesylacetone, technical, mixture of stereo isomers, ≥90% (GC)
C18H30O