EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry

Combining NMR and molecular modelling in a drug delivery context: investigation of the multi-mode inclusion of a new NPY-5 antagonist bromobenzenesulfonamide into beta-cyclodextrin.


PMID 14723963

Abstract

NMR spectroscopic and molecular modelling methods have been employed to describe the complexation of trans-N-4-[N'-(4-chlorobenzoyl)hydrazinocarbonyl]cyclohexylmethyl-4-bromobenzenesulfonamide, a new chemotype of NPY-5 antagonist, and beta-cyclodextrin, revealing the coexistence of two different kinds of 1:1 complexes where conformational changes of the guest compound with respect to the free state are also detected.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

16374
4-Bromobenzenesulfonamide, ≥99.0% (T)
C6H6BrNO2S