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Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry

[Serum concentrations of amitriptyline and its metabolites and clinical effect in depressive patients].


PMID 1478132

Abstract

The serum concentrations of amitriptyline and its 3 metabolites--nortriptyline, 10-hydroxy-amitriptyline and 10-hydroxy-nortriptyline were determined in 18 depressive patients treated with amitriptyline for 6 weeks. The relationships between the serum concentrations and the clinical effects were statistically analyzed and showed significant correlations. The authors suggest that the total TAD serum concentration (280 ng/ml) can be used as the index for clinical efficacy, so far as the above data are concerned.

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