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Chemistry & biology

Profound insights into squalene cyclization.


PMID 15112988

Abstract

In this issue of Chemistry & Biology, our understanding of the formation of pentacyclic hopene from the linear squalene is enhanced by an X-ray structure of a complex between squalene-hopene cyclase and the substrate analog 2-azasqualene.

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04626
Hop-22(29)-ene solution, 0.1 mg/mL in isooctane, analytical standard
C30H50