EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry letters

Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines.


PMID 15149680

Abstract

A series of 1-isoquinolinylguanidines are shown to be potent inhibitors of uPA with selectivity over tPA and plasmin. Potency is enhanced by the presence of a 4-halo and a 7-aryl substituent, particularly when substituted by a 3-carboxylic acid group. Compound 13j (UK-356,202) combines excellent potency and selectivity, and has been selected as a candidate for clinical evaluation.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

456764
3-Carboxyphenylboronic acid, ≥95%
C7H7BO4