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Journal of the American Chemical Society

Highly enantioselective catalytic acyl-pictet-spengler reactions.


PMID 15327311

Abstract

The enantioselective cyclization of N-acyliminium ions generated in situ from tryptamine is promoted with high enantioselectivity by a new chiral thiourea catalyst. This represents the first successful system for asymmetric catalysis of the Pictet-Spengler reaction.