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Basic & clinical pharmacology & toxicology

Effects of perinatal combined exposure to 1,4-dichlorobenzene and 1,1-dichloro-2, 2-bis (p-chlorophenyl) ethylene (p,p'-DDE) on rat female offspring.


PMID 15447738

Abstract

1,4-Dichlorobenzene (DCB) is used as an air freshener and a moth repellent and 1, 1-dichloro-2, 2-bis (p-chlorophenyl) ethylene (p,p'-DDE) is a persistent metabolite of 1, 1, 1-trichloro-2, 2-bis (p-chlorophenyl) ethane (DDT) previously used as a pesticide. DCB concentrations of residential air and oral p,p'-DDE intake via marine products are demonstrated to be higher in Japan than elsewhere. Consequently, human foetuses and neonates may be exposed to DCB and p,p'-DDE via the mother. Therefore, the combined effects of DCB and p,p'-DDE have been investigated in rat female offspring of dams after ingestion of these contaminants. No deteriorated reproductive outcomes of dams and developmental effects on female offspring were observed following oral administration of 25 ppm DCB (approximately 2 mg/kg) and/or 125 ppm p,p'-DDE (approximately 10 mg/kg) to dams. In this study, the thymus weight of female offspring was preserved by DCB at 6 weeks of age though the biological relevance remains unknown. Simultaneous administration of p,p'-DDE with DCB inhibited this phenomenon, through a mechanism still to be elucidated.

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