EMAIL THIS PAGE TO A FRIEND

Organic letters

Notable coordination effects of 2-pyridinesulfonamides leading to efficient aziridination and selective aziridine ring opening.


PMID 15496111

Abstract

[reaction: see text] We have developed, on the basis of a chelation-strategy, an efficient copper-catalyzed aziridination protocol with the use of 5-methyl-2-pyridinesulfonamide and PhI(OAc)(2). The reaction proceeds smoothly under mild conditions to give aziridines in moderate to good yields in the absence of external ligands or bases. The coordination-assisted approach offers the additional benefits that efficient deprotection of the N-substituent and selective aziridine ring-opening are effectively achieved.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

17108
5-Methyl-2-pyridinesulfonamide, ≥97%
C6H8N2O2S