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The Journal of antimicrobial chemotherapy

Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action.


PMID 15650002

Abstract

Pyridine N-oxide derivatives represent a new class of anti-HIV compounds, for which some members exclusively act through inhibition of HIV-1 reverse transcriptase and thus characteristically behave as non-nucleoside reverse transcriptase inhibitors. Other members act, additionally or alternatively, at a post-integrational event in the replication cycle of HIV, that is, at the level of HIV gene expression. Repeated administration of one of the prototype compounds (JPL-32) to DBA/2 and hu-PBMC-SCID mice demonstrated, in the absence of any acute toxicity, protective activity against HIV-induced destruction of CD4 human T lymphocytes.

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131652
Pyridine N-oxide, 95%
C5H5NO