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Bioorganic & medicinal chemistry letters

Novel spiroanellated 1,2,4-trioxanes with high in vitro antimalarial activities.


PMID 15664819

Abstract

A remarkable increase in antimalarial in vitro activity was achieved by integration of spiroadamantane motifs in 6-alkylidene 1,2,4-trioxanes 3a-h via diastereoselective photooxygenation of allylic alcohols and subsequent BF(3)-catalyzed peroxyacetalization with adamantanone to give the active compounds 3e-h.

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T81108
1,3,5-Trioxane, ≥99%
C3H6O3