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Organic & biomolecular chemistry

Synthesis of the beta-hydroxydopa-gamma-hydroxy-delta-sulfinylnorvaline component of ustiloxins A and B.


PMID 15731856

Abstract

The dopa-sulfinylnorvaline component of ustiloxins A and B has been prepared using an Evans salen-Al-catalysed aldol reaction with a 6-mercaptoisovanillin derivative, followed by incorporation of the norvaline group and asymmetric oxidation of the resulting sulfide to give the corresponding sulfoxide.