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Analytical and bioanalytical chemistry

A rapid and sensitive GC-MS method for determination of 1,3-dichloro-2-propanol in water.


PMID 15856197

Abstract

A rapid analytical method for sensitive determination of 1,3-dichloro-2-propanol (1,3-DCP) in river water has been developed. 1,3-DCP is extracted from water with ethyl acetate. After filtration through sodium sulfate the ethyl acetate phase is analyzed by gas chromatography-mass spectrometry. The method uses 1,3-DCP-d5 as internal standard. Different extraction solvents, concentrations of ammonium sulfate in the water samples, and the effect of humic acid were tested and their influence on the recovery of DCP has been evaluated. The method quantification limit was 0.1 microg L(-1). For spiked water samples (0-5.2 microg L(-1), n=21) a repeatability coefficient of variation of 5.4% was obtained. The average recovery rate of 1,3-DCP was 105+/-3% (n=21). Stability tests, which were carried out with Danube river water, led to an estimated 1,3-DCP degradation rate of 0.008+/-0.0008 day(-1) at 6 degrees C.