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Chemical communications (Cambridge, England)

The rhodium catalyzed three-component reaction of diazoacetates, titanium(IV) alkoxides and aldehydes.


PMID 15900348

Abstract

The rhodium(II)-catalyzed three-component reaction of diazoacetates, titanium alkoxides and aldehydes is shown to give alpha-alkoxyl-beta-hydroxyl acid derivatives; the novel C-C bond formation reaction is proposed to occur through oxonium ylides derived from diazo compounds and titanium alkoxides, and followed by intermolecular trapping by aldehydes.