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Bioorganic & medicinal chemistry

Heteroarylisopropylamines as MAO inhibitors.


PMID 15908219

Abstract

The in vitro monoamine oxidase inhibitory (MAOI) activities of 11 heteroarylisopropylamines vis-à-vis MAO-A and MAO-B were described and interpreted in terms of possible interactions with the enzyme active site. Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin.

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471291
Isopropylamine, ≥99.5%
C3H9N
45945
Isopropylamine, anhydrous, analytical standard
C3H9N